Liver-specific TH activity in NAFLD and NASH (P15)

• Subject Area: Gastroenterology
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424957847

We aim to define the effects of local TH availability in the development and progression of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Deiodinases are key enzymes involved in the local activation and inactivation of TH. We will analyse the effect of genetic deletion and siRNA-based knockdown of deiodinases in appropriate rodent models, and study the modulation of genes implicated in local TH availability in human liver samples with different degrees of liver pathology.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 296: Local control of TH action (LocoTact)
• Applicant Institution: Universität Duisburg-Essen
• Project Heads: Professor Dr. Joachim Spranger; Professor Dr. Frank Tacke, Ph.D.; Dr. Eva K. Wirth