Control of deiodinase type 1 (DIO1) expression and its protective function in human hepatocytes (P17)

• Subject Area: Endocrinology, Diabetology, Metabolism
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424957847

Hepatic DIO1 affects systemic and local TH metabolism. Impaired TH signalling negatively affects micro- and macronutrient metabolism, contributing to hyperlipidaemia, fatty liver, fibrosis and eventually carcinogenesis. DIO1 transcription and translation are controlled by endo- and exogenous modifiers, including sex, age, cytokines, selenium, and drugs. We hypothesise that hepatic DIO1 expression can be controlled and increased via a better understanding of and active interference with these modulating factors, thereby enhancing local hepatic TH action and preserving liver health.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 296: Local control of TH action (LocoTact)
• Applicant Institution: Universität Duisburg-Essen
• Project Head: Professor Dr. Lutz Schomburg