Local and global neuronal interactions in movement disorders (B02)

• Subject Area: Cognitive, Systems and Behavioural Neurobiology ; Clinical Neurology; Neurosurgery and Neuroradiology ; Statistical Physics, Nonlinear Dynamics, Complex Systems, Soft and Fluid Matter, Biological Physics
• Term: from 2020 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424778381

This project will quantify local and global neuronal dynamics using measures reflecting excitability and complexity (e.g., 1/f-spectrum, long-range temporal correlations), which will be related to linear and non-linear cross-frequency interactions between remote yet connected structures in cortex-basal ganglia circuitry. We will investigate how DBS-evoked, cortical high-frequency activity relates to therapeutic effects of DBS due to “hyperdirect” antidromic cortex stimulation. Computational modeling will analyze how antidromic cortical stimulation depends on the state of cortical neurons, reflected in the phase and amplitude of ongoing oscillations.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 295: Retuning dynamic motor network disorders using neuromodulation
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Professor Dr. Gabriel Curio; Dr. Vadim Nikulin, Ph.D.