Identifying functional network properties to guide neuromodulation in pediatric and adult hyperkinetic movement disorders (B04)

• Subject Area: Cognitive, Systems and Behavioural Neurobiology ; Clinical Neurology; Neurosurgery and Neuroradiology ; Human Cognitive and Systems Neuroscience
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424778381

Deep brain stimulation (DBS) is an effective treatment for idiopathic dystonia but highly variable in patients with acquired dystonia due to brain lesions. Moreover, some patients may not receive optimal clinical benefits due to the large parameter space and delayed clinical effects of DBS programming. Herein, we will combine advanced neurophysiological and imaging approaches to systematically evaluate the predictive capacity of neurobiological hallmarks in children and adults with dystonia in order to ascertain precise symptom-specific functional network properties of hyperkinesia. The ultimate goal is to guide DBS strategies to optimize therapeutic outcomes in hyperkinesia.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 295: Retuning dynamic motor network disorders using neuromodulation
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Professorin Dr. Andrea Kühn; Dr. Roxanne Lofredi; Dr. Rachel Spooner