Advancing neurostimulation to symptom-related individual adaptive stimulation: theoretical models and clinical application (C04)

• Subject Area: Clinical Neurology; Neurosurgery and Neuroradiology ; Statistical Physics, Nonlinear Dynamics, Complex Systems, Soft and Fluid Matter, Biological Physics
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424778381

In this project, we will develop an innovative protocol for adaptive stimulation in Parkinson’s disease patients. Adaptive stimulation will be based on simultaneous local field potential recordings from the basal ganglia, as well as cortical brain signals (electrocorticography). We will use these to identify new biomarkers that will allow us to individually adapt deep brain stimulation to various symptoms and physiological activity, and include theoretical stimulation models to optimize control variables. By the end of the funding period, we aim to provide an optimized adaptive stimulation protocol suitable for long-term recordings, which can be applied in a clinical study in the second funding period.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 295: Retuning dynamic motor network disorders using neuromodulation
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Professorin Dr. Andrea Kühn; Professor Dr. Michael Rosenblum; Dr. Gerd Helge Schneider