Structural Biology of SARS-CoV-2 by NMR spectroscopy (Covid19-NMR) (B18)

• Subject Area: Structural Biology
• Term: Funded in 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 161793742

COVID19-NMR asks for support for the NMR-based investigation of the untranslated RNA regions and the translated proteome of SARS-CoV-2-Virus as well as its RNA-protein complexes (RNPs) to allow for rapid screening of small molecule substance libraries to support drug development campaigns. The relatively large RNA genome and the reported conservation of the genomic information of human pathogenic coronaviruses in general ensure an impact of such studies beyond the current pandemic crisis.To pursue this task, the DFG-supported collaborative research center CRC902: “Molecular principles of RNA-based regulation” builds a team of six research groups together with international experts on RNA structure prediction, RNA and protein structure determination and RNA ligand libraries. It further gathers expertise in cheminformatics from the company Saverna and fast and transparent documentation and communication of research results provided by the company Signals.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 902: Molecular Principles of RNA-based Regulation
• Applicant Institution: Goethe-Universität Frankfurt am Main, since 3/2020
• Project Head: Professor Dr. Harald Schwalbe, since 3/2020