Cellular and molecular mechanisms of microglia-mediated homeostatic synaptic plasticity (B14*)

• Subject Area: Experimental Models for the Understanding of Nervous System Diseases
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 259373024

Microglia activation in primary lesion sites has been reported in various brain diseases. Lessunderstood, however, remains the relevance of activated microglia in denervated brain regions, whichare not directly affected by the disease but loose part of their input in response to remote cell death.This project focuses on cellular and molecular mechanisms through which microglia mediate the abilityof neurons to compensate for alterations in neural activity, as seen after denervation. In turn, theimpact of neural activity-modulation on cellular and molecular properties of microglia will bedetermined in healthy and denervated brain tissue.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 167: Development, function and potential of myeloid cells in the central nervous system (NeuroMac)
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Andreas Vlachos