Project Details
Decoding and harnessing the impact of immune‐experience on the spatio‐temporal cellular interaction networks underlying bone healing (P01)
Subject Area
Medical Informatics and Medical Bioinformatics
Term
since 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 427826188
Cellular composition, interaction and communication change dynamically during the bone healing process depending on their spatial proximity to each other and to the fracture area. Previous exposure to immunological stimuli, termed immune experience, has been identified as a key factor in determining the cellular communication that enables or prevents efficient healing. Unraveling regulatory to effector T cell ratio as well as an interdependency of bone regeneration and adjacent lymph node immunology as key factors of successful healing led to the aim of systematically decoding the inter-cellular interaction cascades underlying bone healing and its dysfunction, with a specific focus on the impact of previous immune experience, the role of the adaptive immune system and cross-organ communication between bone marrow and adjacent lymph nodes in this project. Mapping the signaling and receptor/ligand landscape will complement our understanding of the cellular communication network underlying bone healing and its modulation in chronological and immunological ageing.
DFG Programme
Collaborative Research Centres
Applicant Institution
shared FU Berlin and HU Berlin through:
Charité - Universitätsmedizin Berlin
Charité - Universitätsmedizin Berlin
Project Heads
Professor Dr. Simon Haas, since 1/2025; Privatdozentin Dr. Katharina Schmidt-Bleek; Professor Dr. Hans-Dieter Volk, until 12/2024