Hydrogels with spatial patterning of biophysical and biochemical properties to guide osteogenesis (P08)

• Subject Area: Medical Informatics and Medical Bioinformatics
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 427826188

Cipitria will continue to develop a material platform using hydrogel technologies that allow a spatial patterning of biophysical and biochemical properties to guide osteogenesis. Cipitria and her team will use previously developed basic principles of hydrogel synthesis and apply them to understand key processes of physiological bone regeneration and their pathological alterations. They will use biophysical cues to modulate cell metabolic activity, proliferation and soft tissue organisation in vitro and will investigate how patterns in biochemical cues can modulate osteogenesis. Alginate matrices primed with a cargo of immune molecules will be used to induce an acellular immune effect on cell metabolic activity, proliferation, soft tissue organisation and osteogenesis in vitro.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1444: Directed Cellular Self-Organisation for Advancing Bone Regeneration
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Dr. Amaia Cipitria, Ph.D., until 6/2021; Professor Dr.-Ing. Georg Duda, since 7/2021