Project Details
Projekt
Disease specific engineering of CAR T cells utilizing chemokine receptors (B01)
Subject Area
Hematology, Oncology
Biochemistry
Immunology
Biochemistry
Immunology
Term
since 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 452881907
B01 will enhance CAR T-cell specificity for the therapy of AML to mitigate on-target/off-leukemia toxicity and engineer cytokine and chemokine switch receptors that improve convert immunosuppressive signals into T-cell stimulatory cues. Preclinical validation will include AML cell lines, primary AML samples, bone marrow organoids, and advanced in vivo models to assess CAR T-cell fitness, exhaustion, homing, and resistance mechanisms within the bone marrow niche. This comprehensive approach will enable to select and develop a preclinical lead for translation into an early-phase clinical trial for refractory AML.
DFG Programme
CRC/Transregios
Applicant Institution
Technische Universität München
Project Heads
Professor Dr. Sebastian Kobold; Professorin Dr. Marion Subklewe
