Project Details
Projekt
Post-transcriptional control of metabolic programs that improve T cell responses against tumors (C02)
Subject Area
Immunology
Term
since 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 452881907
Immune cell therapies have proven very successful in the treatment of some cancers and in a subset of patients. Nevertheless, there is room for improvement for example by manipulating the metabolic programs of T cells in their responses against tumors. The RNA-binding proteins Roquin and Regnase-1 have been shown to control many aspects of T cell biology and metabolism, and they are inactivated in a TCR-strength dependent manner through cleavage by the paracaspase MALT1. In this proposal will unravel the contributions of Roquin- and Regnase-1-mediated gene regulation to anti-tumor responses of CD8+ T cells and evaluate how to use the system in immune cell therapies.
DFG Programme
CRC/Transregios
Applicant Institution
Technische Universität München (TUM)
Project Head
Professor Dr. Vigo Heissmeyer
