Novel modification mapping techniques and efficient RNA-Seq data management (C01)

• Subject Area: Bioinformatics and Theoretical Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 439669440

Epitranscriptomics rely heavily on modification mapping techniques, requiring fast and effective treatment of massive amounts of sequencing data. New modification mapping chemistries lead to new data formats and, like conventional ones, require considerable efforts for data treatment and analysis. Here, a new chemistry will be developed along with mapping, and base calling techniques in a harmonized approach. Standards and tools for quality and performance assessment will be developed to improve accuracy and speed, including machine learning, ultra-fast implementations, and easy-to-use pipelines, which will be applicable to other mapping chemistries, as well.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 319: RMaP: RNA Modification and Processing
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Professor Dr. Mark Helm; Professor Dr. Andreas Hildebrandt; Professor Dr. Bertil Schmidt