Sci-ModoM - the lighthouse database of transcriptome-wide RNA modification and processing (C02)

• Subject Area: Bioinformatics and Theoretical Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 439669440

RNA databases have played a crucial role in RNA biology, but advancing epitranscriptomics requires reliable, FAIR, and user-friendly tools and databases. The Sci-ModoM database supports the Human RNome and other Epitranscriptome Projects by setting standards for RNA modification research and ensuring long-term data management. The project aims to establish the bedRMod format and promote sustainable, data-driven approaches to mapping RNA modifications. Sci-ModoM addresses limitations in existing RNA modification databases by integrating diverse RNA types, including mRNAs, tRNAs and rRNAs, into a unified framework. Expanding Sci-ModoM to capture RNA processing and modifications at the single-molecule level will improve data comparability and drive new discoveries in RNA biology.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 319: RMaP: RNA Modification and Processing
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Professor Dr. Christoph Dieterich; Professor Dr. Andreas Hildebrandt, until 12/2025