Tracking and localised therapy of inflammation and infections on surfaces of established implants (B06)

• Subject Area: Biochemistry ; Biomaterials
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 426335750

Subproject B06 develops an innovative strategy for cell-based targeted drug delivery to combat infections at otherwise inaccessible implant sites. Macrophages, pre-loaded in vitro with detection and therapeutic systems, migrate to sites of infection, where controlled cargo release is triggered by external stimuli such as ultrasound or alternating magnetic fields. Building on systems developed during the first funding period, now multiplexing of antibacterial agents, including bacteriophages, will be explored. To enable autonomous, stimulus-responsive drug release, infection-induced signaling cascades will be integrated into the carrier macrophages. These approaches will be complemented by pharmacokinetic and pharmacodynamic analyses.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 298: Safety Integrated and Infection Reactive Implants
• Applicant Institution: Medizinische Hochschule Hannover
• Project Head: Professorin Dr. Dagmar Wirth