Nanoscale Dynamics and Regulation of Synapsin Condensates (B10)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317475864

Compelling evidence indicates that liquid-liquid phase separation (LLPS) organizes macromolecules into membrane-free compartments, as in the presynapse, where hundreds of synaptic vesicles form biomolecular condensates through the interaction with synapsins, a highly abundant family of synaptic phosphoproteins. We aim to determine the cause-effect relationship between condensate formation and local translation at the pre-synapse, as a function of synaptic activity and phosphorylation cycle.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1286: Quantitative Synaptology
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Professor Dr. Dragomir Milovanovic