Nanoscale Dynamics and Regulation of Synapsin Condensates (B10*)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317475864

Nerve terminals contain hundreds of synaptic vesicles that form tight clusters. Despite being held together, vesicles are highly mobile within these clusters, so that they can be recruited to the membrane upon neuronal activity, for exocytosis. However, little is known about the potential mechanisms of synaptic vesicle cluster regulation. To understand this, in this project, we will analyze the dynamics and regulation of synapsin-bound vesicles both in reconstituted systems and in primary hippocampal neurons.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1286: Quantitative Synaptology
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Dr. Dragomir Milovanovic