Visible Light Induced Homolysis (VLIH) of 3d-Metal-Substrate Complexes (A02)

• Subject Area: Organic Molecular Chemistry - Synthesis and Characterisation
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 444632635

In this project, we will demonstrate that 3d-transition metal-ligand complexes can be rendered capable photoredox catalysts to promote organic transformations. As the key concept it is proposed that suitable metal-ligand-substrate complexes MLn–Z (Z = substrate) can be irradiated by light upon which VLIH will occur to generate M–1Ln + Z• as a starting point for productive organic trans-formations. Two proof of concept studies. i. e. the large-scale synthesis of P2-cyclopentyltetra-hydrofuranyl urethanes (HIV-I-protease inhibitor) and of bicyclic endoperoxides (plasmodium) having IC50 values in the nanomolar region, are envisioned.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 325: Assembly Controlled Chemical Photocatalysis
• Applicant Institution: Technische Universität München (TUM)
• Project Head: Professor Dr. Oliver Reiser