Selective Bond Activation by Modulation of Proton-Coupled Electron Transfer (PCET) and Hydrogen Atom Transfer (HAT) (B06)

• Subject Area: Organic Molecular Chemistry - Synthesis and Characterisation
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 444632635

Based on our previous experience with electron-proton transfer (EPT) mediated (strong), polar X-H bond activation for ring-opening functionalization of cycloalkanols and the thereby noted importance of pre-assembled reaction partners, we plan to deliberatively influence and modulate these crucial interactions to tune reactivity and selectivity. To overcome current limitations of the base-promoted PCET activation of polar X-H bonds and to potentially open up novel transformations, we will focus on a mediator approach as well as on photocatalysts promoting direct substrate interactions (unidirectional PCET). Gained insights will later be transferred to also explore such pre-assembly modulations for selective C-H activation.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 325: Assembly Controlled Chemical Photocatalysis
• Applicant Institution: Universität Regensburg
• Project Head: Professorin Dr. Kirsten Zeitler