Asymmetric protein sorting via localizd translation - The role of ZBP protein in directing mRNA localization and translation

• Applicant: Professor Dr. Stefan Hüttelmaier
• Subject Area: Cell Biology
• Term: from 2007 to 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 33442413

Final Report Abstract

No abstract available

Publications

• (2009). Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs. Rna 15, 104-115
  Weidensdorfer, D., Stohr, N., Baude, A., Lederer, M., Kohn, M., Schierhorn, A., Buchmeier, S., Wahle, E., and Huttelmaier, S.
  (See online at https://doi.org/10.1261/rna.1175909)
• (2012). IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling. Genes & development 26, 176-189
  Stohr, N., Kohn, M., Lederer, M., Glass, M., Reinke, C., Singer, R.H., and Huttelmaier, S.
  (See online at https://doi.org/10.1101/gad.177642.11)
• (2012). IGF2BP1: a post-transcriptional "driver" of tumor cell migration. Cell adhesion & migration 6, 312-318
  Stohr, N., and Huttelmaier, S.
  (See online at https://doi.org/10.4161/cam.20628)
• (2014). The role of the oncofetal IGF2 mRNA- binding protein 3 (IGF2BP3) in cancer. Seminars in cancer biology 29C, 3-12
  Lederer, M., Bley, N., Schleifer, C., and Huttelmaier, S.
  (See online at https://doi.org/10.1016/j.semcancer.2014.07.006)
• (2013). IGF2BP1 promotes mesenchymal cell properties and migration of tumor-derived cells by enhancing the expression of LEF1 and SNAI2 (SLUG). Nucleic acids research 41, 6618-6636
  Zirkel, A., Lederer, M., Stohr, N., Pazaitis, N., and Huttelmaier, S.
  (See online at https://doi.org/10.1093/nar/gkt410)
• (2013). Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression? Cellular and molecular life sciences: CMLS 70, 2657-2675
  Bell, J.L., Wachter, K., Muhleck, B., Pazaitis, N., Kohn, M., Lederer, M., and Huttelmaier, S.
  (See online at https://doi.org/10.1007/s00018-012-1186-z)
• (2013). Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA-binding proteins) is modulated by distinct RNA-binding domains. Biological chemistry 394, 1077-1090
  Wachter, K., Kohn, M., Stohr, N., and Huttelmaier, S.
  (See online at https://doi.org/10.1515/hsz-2013-0111)
• (2014). Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an important protumorigenic factor in hepatocellular carcinoma. Hepatology 59, 1900-1911
  Gutschner, T., Hammerle, M., Pazaitis, N., Bley, N., Fiskin, E., Uckelmann, H., Heim, A., Grobeta, M., Hofmann, N., Geffers, R., Skawran B, Longerich T, Breuhahn K, Schirmacher P, Mühleck B, Hüttelmaier S, Diederichs S
  (See online at https://doi.org/10.1002/hep.26997)