T cell-based mechanisms of immune evasion in aggressive B cell lymphomas (B04)

• Subject Area: Cell Biology ; Hematology, Oncology ; Immunology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 455784452

The activation or restoration of immune cells in the tumor microenvironment is an efficient weapon to improve the prognosis of cancer patients. Although B cell lymphoma patients benefit to some extent from T cell-based immunotherapies, the specific needs of these patients suffering from malignant antigen-presenting B cells, naturally specialized for T cell interaction, are unclear. Thus, we will perform holistic analyses of immune response mechanisms and their abrogation during lymphoma development using autochthonous mouse models of aggressive B cell lymphomas.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1530: Elucidation and targeting of pathogenic mechanisms in B cell malignancies
• Applicant Institution: Universität zu Köln
• Project Head: Professorin Dr. Sandrine Sander