Project Details
Projekt
Role of the complement receptors 1 and 2 as drivers of autoantibody development and their potential as drug targets in pemphigoid diseases (A05)
Subject Area
Immunology
Dermatology
Dermatology
Term
since 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 454193335
The opsonization of protein antigens with complement C3 adducts and their subsequent interaction with complement receptors 1 and 2 on B cells and Follicular Dendritic Cells, drastically increases immunogenicity. Although these processes may equally promote emergence of PD autoantibodies, this potential of CR1/2 has not yet been addressed. Using PD as paradigm autoimmune diseases, A05 will explore the importance of CR1/2 for the emergence of autoimmunity in the EBA mouse model, their role for conversion from inapparent to clinically overt autoimmunity, and their blockade to prevent or halt autoimmune disease.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1526:
Pathomechanisms of Antibody-mediated Autoimmunity (PANTAU): Insights from Pemphigoid Diseases
Applicant Institution
Universität zu Lübeck
