Project Details
Projekt
Microbiota-specific T cell responses in pemphigoid diseases (B08)
Subject Area
Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology
Dermatology
Dermatology
Term
since 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 454193335
The composition of the skin microbiota is altered in pemphigoid diseases (PDs). How this affects specific immune reactions and potentially contributes to skin inflammation is still unknown. We hypothesize that dysregulated microbe-reactive CD4+ T cells driven by an altered skin microbiome may contribute to the pathogenesis of PDs. We will characterize skin microbe-specific T cell responses and correlate these responses with microbial dysbiosis patterns. This will provide knowledge about the contribution of the microbiome and microbe-reactive T cells to PD pathogenesis, instrumental to develop specific therapeutic interventions.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1526:
Pathomechanisms of Antibody-mediated Autoimmunity (PANTAU): Insights from Pemphigoid Diseases
Applicant Institution
Universität zu Lübeck
Project Heads
Professorin Dr. Petra Bacher; Professor Dr. John F. Baines
