Aging at the interface of DNA damage and inflammatory response: Specific impact of the sex (B03)

• Subject Area: Cell Biology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 450627322

Sex-differences have been recognized in life expectancy, immunosenescence and age-associated diseases. Our own preliminary data suggest sex-specific alteration of the DNA damage response (DDR) with age. Due to the recently identified links between these processes, we ask whether DDR, extranuclear DNA sensing and innate immune response, differ between men and women. Our aim is to characterize the crosstalk between aging-associated DDR and inflammation in primary human cells from both sexes.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1506: Aging at Interfaces
• Applicant Institution: Universität Ulm
• Project Heads: Dr. Melanie Rall-Scharpf; Professorin Dr. Elisabeth Maria Wiesmüller