Computational Modeling of Hematopoietic Stem Cell Aging (B06)

• Subject Area: Biogerontology and Geriatric Medicine ; Hematology, Oncology ; Cell Biology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 450627322

Hematopoietic stem cells (HSCs) are surrounded by a multitude of cells that affect their maintenance and differentiation, forming a regulatory environment termed as “niche”. Deregulation of signaling pathways at the niche interface leads to aging. We will simulate this process by using Boolean network models and by applying a co-evolutionary AI-based algorithm to simulate the progression from young to old which will subsequently be validated in vitro.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1506: Aging at Interfaces
• Applicant Institution: Universität Ulm
• Project Heads: Professor Dr. Hartmut Geiger; Professor Dr. Hans A. Kestler