Project Details
Projekt
Dickkopf-3 (DKK3) as a mediator of cardiorenal injury (C10*)
Subject Area
Anatomy and Physiology
Term
since 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 322900939
Tissue fibrosis represents a hallmark of advanced CKD and CVD leading to final organ failure. Recent experimental work in various CKD models has documented the crucial involvement of the Wnt/β-catenin pathway in the development of tubulointerstitial fibrosis and thus progressive CKD. Dickkopf-3 (DKK3) is a member of the Dickkopf protein family, which is closely involved in the regulation of the Wnt/β-catenin signaling. This project aims to systematically dissect the impact of DKK3 on cardiorenal injury and to assess on whether modulation of DKK3 may provide a specific therapeutic target in the management of CKD and its cardiovascular complications.
DFG Programme
CRC/Transregios
Applicant Institution
Rheinisch-Westfälische Technische Hochschule Aachen
Project Heads
Professor Dr. Danilo Fliser, since 1/2022; Dr. Stefan J. Schunk, since 1/2022
