Project Details
Projekt
Microglial-neuronal interaction in the recovery phase of cerebral ischemia
Applicants
Professor Dr. Tim Magnus; Professor Dr. Thomas Oertner
Subject Area
Molecular Biology and Physiology of Neurons and Glial Cells
Experimental Models for the Understanding of Nervous System Diseases
Experimental Models for the Understanding of Nervous System Diseases
Term
since 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 500012246
Recovery after ischemic stroke remains a clinical and experimental challenge. To improve therapeutic efforts, we need a better understanding of the underlying interaction of the main cellular players. In the healthy brain, microglia has an important role aiding synaptic neuronal function, which is currently investigated by Prof. T. Oertner in the ERC Synergy Consortium MicroCOPS. Here, we will make use of the new available mouse models and cutting-edge technology to investigate the role of the microglia neuron interaction in stroke. We hypothesize that activating microglia during the recovery phase of stroke will result in reduced inhibition and improved functional recovery. To verify this hypothesis, we will first analyze microglia at different stage of stroke recovery and focus on pathways that can trigger neuronal responses. Then, we will use our newly developed microglial DREADD mice to alter stroke-induced synaptic plasticity and axonal sprouting, and finally, we will activate microglia and block adenosine through intracerebral nanobody treatment to enhance neuronal recovery.
DFG Programme
Priority Programmes
