Microprotein-mediated responses to vascular damage (A05)

• Subject Area: Anatomy and Physiology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 456687919

We have established a proteo-genomic pipeline to identify microproteins (miPs; aa <100) in endothelial cells under homeostatic conditions as well as changes in miP expression that accompany endothelial cell activation and damage in vitro and in vivo. In this project we plan to unravel the function of 8 damage-regulated endothelial miPs and to determine how they influence endothelial cell function and crosstalk between endothelial cells and other cells in the stroma-vascular compartment. We will also elucidate changes in miP expression following myocardial infarction in mice and in samples from patients with coronary artery disease and acute myocardial infarction.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1531: Damage control by the stroma-vascular compartment
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Dr. Mauro Siragusa