Cardiovascular damage protection by APP/APLP2 (A06)

• Subject Area: Pharmacology ; Cardiology, Angiology
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 456687919

Amyloid precursor protein (APP) and its close homologue APLP2 are expressed in cells of the cardio¬vascular system, but their function is unknown. Starting from our observation that mice with endothelial cell-specific loss of APP and APLP2 show exaggerated responses to myocardial ischemia, we hypothesize that APP/APLP2 are involved in protection against acute damage. We will analyze the protective function of APP/APLP2 in endothelial cells and other cells of the cardiovascular system using different ischemia models, conditional knock-outs and mutant alleles. In vivo analyses will be accompanied by in vitro studies to elucidate the mechanisms underlying the protective function of APP/APLP2.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1531: Damage control by the stroma-vascular compartment
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Professor Dr. Stefan Offermanns