Novel Transformations Mediated by the Persistent NO Radical

• Applicant: Professor Dr. Armido Studer
• Subject Area: Organic Molecular Chemistry - Synthesis and Characterisation
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 506303218

A novel synthetic methodology for the mild oxidative cleavage of various π-systems using radical chemistry will be developed. The proposed strategy utilizes N-nitrosoamines that can be readily prepared. In situ synthesis of such nitroso bifunctional reagents is also feasible. The oxidative cleavage reaction is induced through light irradiation employing LED technology. The developed methods will be applied to the skeletal editing of various natural products. This approach will enable the production of value-added chiral compounds from readily available and inexpensive chiral starting materials. The method is expected to be applicable to the structural reorganization of alkenes, arenes, and polymeric substrates. Furthermore, this approach should allow for the upcycling of waste materials into valuable products, particularly when considering polymeric substrates.

• DFG Programme: Research Grants