Systems biology approach to identify key molecular decision points for intracellular persistence during infection (B04)

• Subject Area: Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 492620490

B04 deploys an innovative approach to uncover key molecular decisions for sustaining or aborting a persistent state during infection using the well-established model system of Salmonella infection of macrophages. In the long term, B04 aims to investigate if their findings are pathogen- or host cell-specific, which will determine the need for broad-spectrum or targeted therapies. Their methods can be easily adapted to directly investigate if the key pathways that regulate Salmonella persistence that B04 will uncover will also influence persistence by other pathogens, such as Chlamydia trachomatis or Yersinia pseudotuberculosis.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1583: Decisions in Infectious Diseases (DECIDE)
• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Head: Dr. Ana Rita Brochado