Formation, composition and role of extracellular vesicles in the ischemic heart (P02)

• Subject Area: Cell Biology ; Animal Physiology and Biochemistry ; Developmental Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 467522186

This project takes advantage of an ischemia models in mice (Mus) and the highly regenerative spiny mice (Acomys) to ask how a specific population of extracellular vesicles (EV) at the plasma membrane of cardiac fibroblasts is formed and how these vesicles affect the activity of other cardiac cells. The project will analyze the EV composition their injury induced changes as well as their uptake and cardioprotective and/or angiogenic capacity in target cells.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1557: Functional Plasticity encoded by Cellular Membrane Networks
• Applicant Institution: Universität Osnabrück
• Project Head: Professorin Dr. Kerstin Bartscherer