Project Details
Projekt
Biological function of selenoprotein P: Binding characteristics and cellular localization
Applicant
Professor Dr. Helmut Sies
Subject Area
Biochemistry
Term
from 2000 to 2007
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 5237252
Among the selenoproteins, selenoprotein P (SeP) is particularly rich in selenocysteine (8-10 SeCys). Since this protein also contains poly-histidine domains and a high number of lysine residues, capable of binding to glycosaminoglycans, e g heparan sulfates, a strategically interesting positioning on the cell surface was proposed as a basis for a protective function on endothelial cells. The project is to characterize the interaction of SeP with artificially generated surfaces, endothelial cells and other cell types. Potentiation of a protective function against peroxynitrite and other oxidants by preferential localisation of the protein is to be examined. This question is important for evaluating the role of SeP in inflammatory processes and oxidative stress in general.
DFG Programme
Priority Programmes
Participating Person
Professor Dr. Peter Brenneisen, Ph.D.
