Detailseite
Projekt
Untersuchungen zur antioxidativen Funktion von Selenoprotein P in Endothelzellen und Astrozyten (Characterisation of the antioxidative function of Selenoprotein P in endothelial cells and astrocytes
Antragsteller
Professor Dr. Helmut Sies
Fachliche Zuordnung
Biochemie
Förderung
Förderung von 2000 bis 2007
Projektkennung
Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5237252
Among the selenoproteins, selenoprotein P (SeP) is particularly rich in selenocysteine (8-10 SeCys). Since this protein also contains poly-histidine domains and a high number of lysine residues, capable of binding to glycosaminoglycans, e g heparan sulfates, a strategically interesting positioning on the cell surface was proposed as a basis for a protective function on endothelial cells. The project is to characterize the interaction of SeP with artificially generated surfaces, endothelial cells and other cell types. Potentiation of a protective function against peroxynitrite and other oxidants by preferential localisation of the protein is to be examined. This question is important for evaluating the role of SeP in inflammatory processes and oxidative stress in general.
DFG-Verfahren
Schwerpunktprogramme
Beteiligte Person
Professor Peter Brenneisen, Ph.D.
