The post-translationally modified neuroblastoma proteome as a source for druggable vulnerabilities (A06)

• Subject Area: Hematology, Oncology ; Biochemistry ; Bioinformatics and Theoretical Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 493872418

The project analyzes spatial and temporal changes in NB proteomes during treatment to characterize tumor evolution and identify therapeutic targets. Key proteins and PTM signatures associated with various cellular treatment responses, cell identities and treatment resistance will be identified. Mechanisms controlling PTM-dependent processes through genetic and pharmacological perturbations of PTM regulators will also be described. The focus will be on developing clinically actionable panel assays for key diagnostic signatures for risk or treatment stratification and drug-related vulnerabilities.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1588: Decoding and Targeting Mechanisms of Neuroblastoma Evolution
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Dr. Jan Dörr; Dr. Philipp Mertins