Neutrophin-Regulation in Depressionsmodellen der Maus vor und nach antidepressiver Behandlung

• Antragsteller: Professor Dr. Peter Gass; Professor Dr. Rainer Hellweg
• Fachliche Zuordnung: Klinische Psychiatrie, Psychotherapie und Kinder- und Jugendspychiatrie
• Förderung: Förderung von 2007 bis 2011
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 52548421

• Erstellungsjahr: 2010

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Depression-prone mice with reduced glucocorticoid receptor expression display an altered stressdependent regulation of brain-derived neurotrophic factor and activity-regulated cytoskeleton associated protein. Journal of Psychopharmacology [epub ahead of print]
  Molteni R, Calabrese F, Chourbaji S, Brandwein C, Racagni G, Gass P, Riva M
  
• Differential regulation of neurotrophins and serotonergic function in mice with genetically reduced glucocorticoid receptor expression. Experimental Neurology 204: 307-316, 2007
  Schulte-Herbrüggen O, Hellweg R, Chourbaji S, Ridder S, Brandwein C, Gass P, Hörtnagl H
  
• Olfactory bulbectomy in mice leads to increased BDNF levels and decreased serotonin turnover in depression-related brain areas. Neurobiology of Disease 25: 1-7, 2007
  Hellweg R, Züger M, Fink K, Hörtnagl H, Gass P
  
• Nature vs. nurture: can enrichment rescue the behavioural phenotype of BDNF heterozygous mice? Behavioural Brain Research 192: 254-258, 2008
  Chourbaji S, Brandwein C, Vogt MA, Dormann C, Hellweg R, Gass P
  
• Effects of escitalopram on the regulation of brain-derived neurotrophic factor and nerve growth factor protein levels in a rat model of chronic stress. Journal of Neuroscience Research 87: 2551-60, 2009
  Schulte-Herbrüggen O, Fuchs E, Abumara N, Ziegler A, Danker-Hopfe H, Hiemke C, Hellweg R
  
• Serum and brain tissue levels of brain-derived neurotrophic factor after electroconvulsive treatment. Pharmacopsychiatry 42: 270-276, 2009
  Sartorius A, Hellweg R, Litzke J, Vogt MA, Dormann C, Vollmayr B, Danker-Hopfe H, Gass P
  
• Acute exercise ameliorates reduced brain-derived neurotrophic factor in patients with panic disorder. Psychoneuroendocrinology 35: 364-8, 2010
  Ströhle A, Stoy M, Graetz B, Scheel M, Wittmann A, Gallinat J, Lang UE, Dimeo F, Hellweg R
  
• Increased stress reactivity is associated with cognitive deficits and decreased hippocampal brainderived neurotrophic factor in a mouse model of affective disorders. Journal of Psychiatric Research 44: 566-75, 2010
  Knapman A, Heinzmann JM, Hellweg R, Holsboer F, Landgraf R, Touma C
  
• Peripheral brain-derived neurotrophic factor (BDNF) as biomarker for affective disorders? International Journal of Neuropsychopharmacology 13: 1-4, 2010
  Gass P, Hellweg R
  
• Voluntary exercise induces anxiety-like behaviour in C57BL/6J mice correlating with hippocampal neurogenesis. Hippocampus 20: 364-376, 2010
  Fuss J, Ben Abdallah N, Vogt MA, Touma C, Pacifici PG, Palme R, Witzemann V, Hellweg R, Gass P