Non-coding RNAs regulating cardiac innervation (B11*)

• Subject Area: Anatomy and Physiology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 403584255

The sympathetic nervous system tightly regulates cardiac function. Preliminary experiments revealed inflammation and pathological remodeling of heart-innervating sympathetic ganglia during cardiac disease in humans and mice, and effective preservation of cardiac function by local, intraganglionic targeting of inflammatory cells. Non-coding RNAs represent attractive therapeutic targets and we have identified several ncRNAs that are associated with activation of ganglionic macrophages and glial cells during heart disease after extensive transcriptomic analyses. This project aims at the intraganglionic manipulation of these cell type-specific ncRNAs to test their therapeutic applicability for cardiac disease.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 267: Non-coding RNA in the cardiovascular system
• Applicant Institution: Technische Universität München (TUM)
• Project Head: Professor Dr. Stefan Engelhardt