Die Rolle von NO bei der Initiierung und Modulierung hypoxischer Antworten

• Antragsteller: Professor Dr. Bernhard Brüne
• Fachliche Zuordnung: Biochemie
• Förderung: Förderung von 2001 bis 2009
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5351461

• Erstellungsjahr: 2009

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• (2005). NO restores HIF-la hydroxylation during hypoxia: role of reactive oxygen species. Free Rad Biol & Med 39, 925-36
  Callapina M., Zhou J., Schmid T., Köhl R., and Brüne B.
  
• (2006). Calpain mediates a pVHL proteinindependent destruction of HIF-la. Mol Biol Cell 17, 1549-58
  Zhou J., Köhl R., Herr B., Frank R., and Brüne B.
  
• (2006). Hypoxia and HIF-la in protecfion from drug-induced apoptosis in A549 cells. Cell Death & Differ 13, 1611-3
  Schnitzer S.E., Schmid T., Zhou J., and Brüne B.
  
• (2006). Reactive oxygen species attenuate NO-mediated HlF- l a stabilization. Free Rad Biol & Med 40, 1430-42
  Köhl R., Zhou J., and Brüne B.
  
• (2006). Tumor hypoxia and cancer progression. Cancer Letters 237, 10-21
  Zhou J., Schmid T., Schnitzer S., and Brüne B.
  
• (2007). Hypoxia inducible factor-la (HIF-la) under the control of nitric oxide. Methods in Enzymology 435, 461-76
  Brüne B., and Zhou J.
  
• (2007). Nitric oxide and superoxide: interference with hypoxic signaling. Cardiovasc Res 75, 275-82
  Brüne B.. and Zhou J.
  
• (2007). The interaction of superoxide with nitric oxide destabilizes ofhypoxia inducible factors-la. Cell & Mol Life Sci, 64, 3295-305
  Herr B., Zhou J., Dröse S., and Brüne B.
  
• (2007). Thioredoxin 1 and thioredoxin 2 have opposed regulatory functions on hypoxia inducible factor-la. J Biol Chem 282, 7482- 90
  Zhou J., Damdimopoulos A.E., Spyrou G., and Brüne B.
  
• (2008). Nitric oxide, apoptosis and macrophage polarizafion during tumor progression. Nitric Oxide 19, 95-102
  Weigert A., and Brüne B.
  
• (2008). The milochondrial thioredoxin system regulates nitric oxide-induced HIF-la protein. Free Rad Biol & Med 44, 91-8
  Zhou J., Eleni C., Spyrou G., and Brüne B.
  
• (2009). HlF-1 in the inflammaiory microenvironment. Exp Cell Res. 315,1791-97
  Dehne N., and Brüne B.
  
• (2009). Nitric oxide causes macrophage migrafion via HIF-1- stimulated small GTPase Cdc42/Rac1, Free Rad. Biol. & Med.
  Zhou J., Dehne N., and Brüne B.