Regulation zellulärer Funktionen durch den CA2+-aktivierten K+-Kanal vom BK-Typ

• Antragsteller: Professor Dr. Peter Ruth
• Fachliche Zuordnung: Pharmakologie
• Förderung: Förderung von 2002 bis 2009
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5364270

• Erstellungsjahr: 2008

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiency. Proc Natl Acad Sci USA 2004; 101:9474-9478
  Sausbier M., Hu H, Arntz C, Feil S, Kamm S, Adelsberger H, Sausbier U, Sailer CA, Feil R, Hofmann F, Korth M, Shipston MJ, Knaus HG, Wolfer DP, Pedroarena CM, Storm JF, Ruth P
  
• Deletion of the Ca2+-activated potassium (BK) channel alpha subunit but not the BK betal-subunit leads to progressive hearing loss. Proc Natl Acad Sci USA 2004; 101: 12922-12927
  Ruttiger L, Sausbier M, Zimmermann U, Winter H, Braig C, Engel J, Knirsch M, Arntz C, Langer P, Hirt B, Muller M, Kopschall I, Pfister M, Munkner S, Rohbock K, Pfaff I, Rusch A, Ruth P, Knipper M
  
• Distinct stoichiometry of BKCa channel tetramer phosphorylation specifies channel activation and inhibition by cAMP-dependent protein kinase. Proc Natl Acad Sci USA 2004; 101:11897-11902
  Tian L, Coghill LS, McClafferty H, MacDonald SH, Antoni FA, Ruth P, Knaus HG, Shipston MJ
  
• Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel deficient mice. Circulation 2005; 112:60-68
  Sausbier M, Arntz C, Bucurenciu I, Feil S, Zhao H, Sausbier U, Kamm S, Zhou X-B, Essin K, Sailer CA, Krippeit-Drews P, Feil R, Hofmann F, Knaus HG, Kenyon C, Shipston MJ, Storm JF, Neuhuber W, Korth M, Schubert R, Gollasch M, Ruth P
  
• Distal colonic K+ secretion occurs via BK channels. J Am Soc Nephrol 2006; 17: 1275-1282
  Sausbier M, Matos JE, Sausbier U, Arntz C, Neuhuber W, Ruth P, Leipziger J
  
• Distribution of Ca2+- Activated K+ Channels of the BK-Type in the Mouse Brain. Histochem Cell Biol 2006; 125: 725-741
  Sausbier U, Sausbier M, Sailer C, Arntz C, Knaus H-G, Neuhuber W, Ruth P
  
• The role of BKCa channels in electrical signal encoding in the mammalian auditory periphery. J Neuroscience 2006; 26: 6181-6189
  Oliver D, Taberner A, Thurm H, Sausbier M, Arntz C, Ruth P, Fakler B, Liberman MC
  
• Electrophysiology of the phagocyte respiratory burst. Focus on "Large-conductance calcium-activated potassium channel activity is absent in human and mouse neutrophils and is not required for innate immunity". Am J Physiol Cell Physiol 2007; 293: C30-32
  DeCoursey T
  
• Hypothalamic-Pituitary-Adrenal Axis Hyporesponsiveness to Restraint Stress in Mice Deficient for Large-Conductance Ca2+- and Voltage-Activated Potassium (BK) Channels. Endocrinology 2007; 148: 5496-5506
  Brunton PJ, Sausbier M, Wietzorrek G, Sausbier U, Knaus HG, Russell JA, Ruth P, Shipston MJ
  
• Large-conductance calcium-activated potassium channel activity is absent in human and mouse neutrophils and is not required for innate immunity. Am J Physiol Cell Physiol 2007; 293: C45-54
  Essin K, Salanova B, Kettritz R, Sausbier M, Luft FC, Kraus D, Bohn E, Autenrieth IB, Peschel A, Ruth P, Gollasch M
  
• Reduced rather than enhanced cholinergic airway constriction in mice with ablation of the large conductance Ca2+- activated K+ channel. FASEB J 2007; 21: 812-822
  Sausbier M, Zhou X-B, Beier C, Sausbier U, Wolpers D, Maget S, Martin C, Dietrich A, Ressmeyer AR, Renz H, Schlossmann J, Hofmann F, Neuhuber W, Gudermann T, Uhlig S, Korth M, Ruth P
  
• Role of cholinergic-activated KCa1.1 (BK), KCa3.1 (SK4) and KV7.1 (KCNQ1) channels in mouse colonic C1-secretion. Acta Physiol (Oxf). 2007;189:251-258
  Matos JE, Sausbier M, Beranek G, Sausbier U, Ruth P, Leipziger J
  
• The role of the BK channel in potassium homeostasis and flow-induced renal potassium excretion. Kidney Int 2007; 72:566-573
  Rieg T, Vallon V, Sausbier M, Sausbier U, Kaissling B, Ruth P, Osswald H
  
• Aldosterone increases KCal.1 (BK) channel-mediated colonic K+ secretion. J Physiol. 2008; 586:4251-64
  Sorensen MV, Matos JE, Sausbier M, Sausbier U, Ruth P, Praetorius HA, Leipziger J