Molekulare Charakterisierung des globalen Virulenzregulators sae von Staphylococcus aureus in vitro und in vivo

• Antragstellerin: Professorin Dr. Christiane Wolz
• Fachliche Zuordnung: Parasitologie und Biologie der Erreger tropischer Infektionskrankheiten
• Förderung: Förderung von 2004 bis 2009
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5433470

• Erstellungsjahr: 2010

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• 2005. Molecular basis of florfenicol-induced increase in adherence of Staphylococcus aureus strain Newman. J Antimicrob Chemother 56:315-23
  Blickwede, M., R. Goethe, C. Wolz, P. Valentin-Weigand, and S. Schwarz
  
• 2005. Role of Staphylococcus aureus global regulators sae and sigmaB in virulence gene expression during device-related infection. Infect Immun 73:3415-21
  Goerke, C., U. Flückiger, A. Steinhuber, V. Bisanzio, M. Ulrich, M. Bischoff, J. M. Patti, and C. Wolz
  
• 2005. sae is essential for expression of the staphylococcal adhesins Eap and Emp. Microbiology 151:1789-800
  Harraghy, N., J. Kormanec, C. Wolz, D. Homerova, C. Goerke, K. Ohlsen, S. Qazi, P. Hill, and M. Herrmann
  
• 2006. Influence of the two-component system SaeRS on global gene expression in two different Staphylococcus aureus strains. J Bacteriol 188:7742-58
  Rogasch, K., V. Ruhmling, J. Pane-Farre, D. Hoper, C. Weinberg, S. Fuchs, M. Schmudde, B. M. Broker, C. Wolz, M. Hecker, and S. Engelmann
  
• 2006. Staphytococcus aureus CcpA affects virulence determinant production and antibiotic resistance. Antimicrob Agents Chemother 50:1183-94
  Seidl, K., M. Stucki, M. Ruegg, C. Goerke, C. Wolz, L. Harris, B. Berger-Bachi, and M. Bischoff
  
• 2007. sigmaB and the sigmaB-dependent arlRS and yabJ-spoVG loci affect capsule formation in Staphylococcus aureus. Infect Immun 75:4562-71
  Meier, S., C. Goerke, C. Wolz, K. Seidl, D. Homerova, B. Schulthess, J. Kormanec, B. Berger-Bachi, and M. Bischoff
  
• 2007. The staphylococcal respiratory response regulator SrrAB induces ica gene transcription and polysaccharide intercellular adhesin expression, protecting Staphylococcus aureus from neutrophil killing under anaerobic growth conditions. Mol Microbiol 65:1276-87
  Ulrich, M., M. Bastian, S. E. Cramton, K. Ziegler, A. A. Pragman, A. Bragonzi, G. Memmi, C. Wolz, P. M. Schlievert, A. Cheung, and G. Döring
  
• 2008. Bioluminescence imaging to study the promoter activity of hla of Staphylococcus aureus in vitro and in vivo. Int J Med Microbiol 298:599-605
  Steinhuber, A., R. Landmann, C. Goerke, C. Wolz, and U. Flückiger
  
• 2008. Staphylococcus aureus CcpA affects biofilm formation. Infect Immun 76:2044-50
  Seidl, K., C. Goerke, C. Wolz, D. Mack, B. Berger-Bachi, and M. Bischoff
  
• 2008. The virulence regulator Sae of Staphylococcus aureus: promoter activities and response to phagocytosis-related signals. J Bacteriol 190:3419-28
  Geiger, T., C. Goerke, M. Mainiero, D. Kraus, and C. Wolz
  
• 2009. A point mutation in the sensor histidine kinase SaeS of Staphylococcus aureus strain Newman alters the response to biocide exposure. J Bacteriol 191:7306-14
  Schäfer, D., T. T. Lam, T. Geiger, M. Mainiero, S. Engelmann, M. Hussain, A. Bosserhoff, M. Frosch, M. Bischoff, C. Wolz, J. Reidl, and B. Sinha
  
• 2009. Differential target gene activation by the Staphylococcus aureus two-component system saeRS. J Bacteriol 192:613-623
  Mainiero, M., C. Goerke, T. Geiger, C. Gonser, S. Herbert, and C. Wolz