Die Bedeutung der Autoantikörper gegen den AT1-Rezeptor und des uteroplazentären Renin-Angiotensin Systems in der Pathophysiologie der Präeklampsie

• Antragsteller: Professor Dr. Ralf Dechend
• Fachliche Zuordnung: Kardiologie, Angiologie
• Förderung: Förderung von 2007 bis 2012
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 54452628

• Erstellungsjahr: 2011

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Angiogenesis factors and preeclampsia. Nature Medicine, Vol. 14. 2008, Issue 11, pp. 1187 - 1188. Seminars in Nephrology, Vol. 31. 2011, Issue 1, pp. 33–46. http://dx.doi.org/10.1016/j.semnephrol.2010.10.004
  Dechend, Ralf & Luft, Friedrich C.
  
• AT1-receptor autoantibodies and uteroplacental RAS in pregnancy and pre-eclampsia. Journal of Molecular Medicine, Vol. 86. 2008, Issue 6, pp. 697-703.
  Herse, Florian; Staff, Anne Cathrine; Hering, Lydia; Müller, Dominik N.; Luft, Friedrich C. & Dechend, Ralf
  
• Endovascular trophoblast invasion, spiral artery remodelling and uteroplacental haemodynamics in a transgenic rat model of pre-eclampsia. Placenta, Vol. 29. 2008, Issue 7, pp. 614–623.
  Geusens, N.; Verlohren, S.; Luyten, C.; Taube, M.; Hering, L.; Vercruysse, L.; Hanssens, M.; Dudenhausen, J.W.; Dechend, R. & Pijnenborg, R.
  
• Circulating and Placental Growth-Differentiation Factor 15 in Preeclampsia and in Pregnancy Complicated by Diabetes Mellitus. Hypertension, 54. 2009, Issue 1, pp. 106-112.
  Sugulle, Meryam; Dechend, Ralf; Herse, Florian; Weedon-Fekjaer, M. Susanne; Johnsen, Guro M.; Brosnihan, K. Bridget; Anton, Lauren; Luft, Friedrich C.; Wollert, Kai C.; Kempf, Tibor & Staff, Anne Cathrine
  
• Hypertension in response to autoantibodies to the angiotensin II type I receptor (AT1-AA) in pregnant rats: role of endothelin-1 Hypertension, Vol. 54. 2009, Issue 4, pp.905-909.
  LaMarca, Babbette; Parrish, Marc; Ray, Lillian Fournier; Murphy, Sydney R.; Roberts, Lyndsay; Glover, Porter; Wallukat, Gerd; Wenzel, Katrin; Cockrell, Kathy; Martin, James N.; Ryan, Michael J. & Dechend, Ralf
  
• Prevalence of Agonistic Autoantibodies Against the Angiotensin II Type 1 Receptor and Soluble fms-Like Tyrosine Kinase 1 in a Gestational Age-Matched Case Study. Hypertension, Vol. 53. 2009, Issue 2, pp. 393-398.
  Herse, Florian; Verlohren, Stefan; Wenzel, Katrin; Pape, Juliane; Muller, Dominik N.; Modrow, Susanne; Wallukat, Gerd; Luft, Friedrich C.; Redman, Christopher W.G. & Dechend, Ralf
  
• Alpha1A-adrenergic receptordirected autoimmunity induces left ventricular damage and diastolic dysfunction in rats. PLoS One, Vol. 5. 2010, Issue 2: e9409.
  Wenzel, Katrin; Wallukat, Gerd; Qadri, Fatimunnisa; Hubner, Norbert; Schulz, Herbert; Hummel, Oliver; Herse, Florian; Heuser, Arnd; Fischer, Robert; Heidecke, Harald; Luft, Friedrich C.; Muller, Dominik N.; Dietz, Rainer & Dechend, Ralf
  
• Changes in endovascular trophoblast invasion and spiral artery remodelling at term in a transgenic preeclamptic rat model. Placenta, Vol. 31. 2010, Issue 4, pp. 320–326.
  Geusens, N.; Hering, L.; Verlohren, S.; Luyten, C.; Drijkoningen, K.; Taube, M.; Vercruysse, L.; Hanssens, M.; Dechend, R. & Pijnenborg, R.
  
• Effects of circulating and local uteroplacental angiotensin II in rat pregnancy. Hypertension, Vol.56. 2010, Issue 2, pp.311-318.
  Hering, Lydia; Herse, Florian; Geusens, Nele; Verlohren, Stefan; Wenzel, Katrin; Staff, Anne C.; Brosnihan, K. Bridget; Huppertz, Berthold; Luft, Friedrich C.; Muller, Dominik N.; Pijnenborg, Robert; Cartwright, Judith E. & Dechend, Ralf
  
• Increased Angiotensin II in the Mesometrial Triangle of a Transgenic Rat Model of Preeclampsia Hypertension. Hypertension, Vol. 55. 2010, Issue 2, pp. 562-566.
  Brosnihan, K. Bridget; Hering, Lydia; Dechend, Ralf; Chappell, Mark C. & Herse, Florian
  
• Inhibition of trophoblastinduced spiral artery remodeling reduces placental perfusion in rat pregnancy, Hypertension Vol.56. 2010, Issue 2, pp. 304-310.
  Verlohren, Stefan; Geusens, Nele; Morton, Jude; Verhaegen, Iris; Hering, Lydia; Herse, Florian; Dudenhausen, Joachim W.; Muller, Dominik N.; Luft, Friedrich C.; Cartwright, Judith E.; Davidge, Sandra T.; Pijnenborg, Robert & Dechend, Ralf
  
• The effect of immune factors, tumor necrosis factor-alpha, and agonistic autoantibodies to the angiotensin II type I receptor on soluble fmslike tyrosine-1 and soluble endoglin production in response to hypertension during pregnancy. American Journal of Hypertension, Vol. 23. 2010, Issue 8, pp. 911-916.
  Parrish, M. R.; Murphy, S. R.; Rutland, S.; Wallace, K.; Wenzel, K.; Wallukat, G.; Keiser, S.; Ray, L. F.; Dechend, R.; Martin, J. N.; Granger, J. P. & LaMarca, B.
  
• Adipose tissue-derived soluble fms-like tyrosine kinase 1 is an obesity-relevant endogenous paracrine adipokine. Hypertension, Vol. 58. 2011, Issue 1, pp.37-42.
  Herse, Florian; Fain, John N.; Janke, Juergen; Engeli, Stefan; Kuhn, Christian; Frey, Norbert; Weich, Herbert A.; Bergmann, Astrid; Kappert, Kai; Karumanchi, S. Ananth; Luft, Friedrich C.; Muller, Dominik N.; Staff, Anne C. & Dechend, Ralf
  
• Angiogenic growth factors in the diagnosis and prediction of pre-eclampsia Clinical Science, Vol. 122. 2012, pp.43–52.
  Verlohren, Stefan; Stepan, Holger & Dechend, Ralf
  
• Angiotensin II Type 1 Receptor Antibodies and Increased Angiotensin II Sensitivity in Pregnant Rats. Hypertension, Vol. 58. 2011, pp. 77-84.
  Wenzel, Katrin; Rajakumar, Augustine; Haase, Hannelore; Geusens, Nele; Hubner, Norbert; Schulz, Herbert; Brewer, Justin; Roberts, Lyndsay; Hubel, Carl A.; Herse, Florian; Hering, Lydia; Qadri, Fatimunnisa; Lindschau, Carsten; Wallukat, Gerd; Pijnenborg, Robert; Heidecke, Harald; Riemekasten, Gabriela; Luft, Friedrich C.; Muller, Dominik N.; ... & Dechend, Ralf
  
• Heparin Strongly Induces Soluble fms-Like Tyrosine Kinase 1 Release In Vivo and In Vitro. Arteriosclerosis, Thrombosis, and Vascular Biology, Volume 31. 2011, Issue 12, pp. 2972-2974.
  Searle, Julia; Mockel, Martin; Gwosc, Stefanie; Datwyler, Saul A.; Qadri, Fatimunnisa; Albert, Gesa I.; Holert, Fabian; Isbruch, Annette; Klug, Lars; Muller, Dominik N.; Dechend, Ralf; Muller, Reinhold; Vollert, Joern O.; Slagman, Anna; Mueller, Christian & Herse, Florian
  
• Hypertension in Response to AT1-AA: Role of Reactive Oxygen Species in Pregnancy-Induced Hypertension. American Journal of Hypertension, Vol.24. 2011, Issue 7, pp. 835-840.
  Parrish, M. R.; Wallace, K.; Tam, K. B. T.; Herse, F.; Weimer, A.; Wenzel, K.; Wallukat, G.; Ray, L. F.; Arany, M.; Cockrell, K.; Martin, J. N.; Dechend, R. & LaMarca, B.
  
• Hypertension in response to placental ischemia during pregnancy: role of B lymphocytes. Hypertension, Vol.57. 2011, Issue 4, pp. 865-71.
  LaMarca, Babbette; Wallace, Kedra; Herse, Florian; Wallukat, Gerd; Martin, James N.; Weimer, Abram & Dechend, Ralf
  
• Placenta messages to the mother: not just debris, Hypertension 2011 Hypertension, Vol. 59. 2012, Issue 2, pp. 191-193.
  Dechend, Ralf & Staff, Anne Cathrine