Structural mechanism of the activation of RIG-I by viral RNA (A13)

• Fachliche Zuordnung: Virologie
• Förderung: Förderung von 2005 bis 2010
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5483103

The ATPase RIG-I senses the presence of viral RNA in the cytoplasm and initiates a signal transduction cascade that leads to stimulation of the innate immune response. We have obtained first structural insights into recognition of viral RNA by RIG-I. In this proposal we want to derive a complete structural mechanism of activation of RIG-I by viral RNA. In collaboration we address by structural, biochemical and in vivo functional approaches, how RIG-I binds viral RNA and how RNA and ATP binding induce a signaling conformation in RIG-I that leads to stimulation of the innate immune response.

• DFG-Verfahren: Sonderforschungsbereiche
• Teilprojekt zu: SFB 455: Virale Funktionen und Immunmodulation
• Antragstellende Institution: Ludwig-Maximilians-Universität München
• Teilprojektleiter: Professor Dr. Karl-Peter Hopfner