Gait disturbances in Parkinson’s disease: from multifactorial home monitoring towards adaptive neuromodulation therapies (C05*)

• Subject Area: Experimental Models for the Understanding of Nervous System Diseases ; Clinical Neurology; Neurosurgery and Neuroradiology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424778381

Building on the previous results of B05, C05 now aims to develop the first phenotype specific neuromodulation treatment specifically designed to retune gait disturbances in patients with Parkinson's disease (PD). By combining in-depth laboratory assessments of gait with long-term multimodal home monitoring, we will develop multifactorial and personalized models to identify neurophysiological biomarkers encoding gait and predicting gait disturbances. We will then test neuromodulation protocols based on these gait-specific neurophysiological biomarkers in patients, thus taking the final step to propose an effective therapeutic strategy for gait disorders in PD.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 295: Retuning dynamic motor network disorders using neuromodulation
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Professor Dr.-Ing. Muthuraman Muthuraman, Ph.D.; Dr.-Ing. Chiara Palmisano; Dr. Nicoló Gabriele Pozzi