FOR 426:  Complex RNA-protein interactions in the maturation and function of eukaryotic mRNA

• Fachliche Zuordnung: Biologie
• Förderung: Förderung von 2001 bis 2006
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5468076

Keine Zusammenfassung vorhanden

• DFG-Verfahren: Forschungsgruppen

Projekte

• 3`-Processing of mRNA: Composition and dynamics of the processing complex and reconstitution of selected factors (Antragsteller Wahle, Elmar )
• Characterization of the endo/exonuclease Tb08 as a core component of the RNA editing RNP in African trypanosomes (Antragsteller Göringer, H. Ulrich )
• Complex RNA-protein interactions in the maturation and functions of eukaryotic mRNA (Antragsteller Wahle, Elmar )
• Crystallographic studies on snRNP-and SMN-Associated DExD/H-box proteins and on the editosome-specific nuclease TbMP42 (Antragsteller Ficner, Ralf )
• Dynamic assembly of localized mRNP complexes in yeast (Antragsteller Jansen, Ralf-Peter )
• Molecular dissection of the assembly pathway of spliceosomal U snRNPs (Antragsteller Fischer, Utz )
• Molecular mechanisms of hereditary thrombophilia: physiological function of prothrombin mRNA 3` end maturation (Antragsteller Kulozik, Ph.D., Andreas Eckhard )
• Purification of RNP complexes involved in RNA nuclear export (Antragsteller Mattaj, Iain W. )
• Regulation of mammalian mRNA splicing by CA repeat enhancer elements (Antragsteller Bindereif, Albrecht )
• Structure and remodelling of the spliceosomal RNP network (Antragsteller Lührmann, Reinhard )
• The role of the poly(A)-specific ribonuclease (PARN) in mRNA decay (Antragsteller Wahle, Elmar )
• The translationally regulated msl-2 mRNP from Drosophila (Antragsteller Hentze, Matthias )

• Sprecher: Professor Dr. Elmar Wahle