Eukaryotic cells achieve their high functional diversity by compartimentalization which locates specific functions to cellular subcompartments that are often delineated by membranes. Compartimentalization depends on mechanisms that allow a directed trafficking of molecules such as proteins, lipids or nucleic acids between the different cellular compartments. Projects in the collaborative research centre 523 focus on the transport of proteins and RNA across the nuclear pore, the retention and sorting of membrane proteins within the secretory and endocytic route, the formation, transport and fusion of transport vesicles.
DFG Programme
Collaborative Research Centres
International Connection
USA
Completed projects
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A01 - Regulation of the nucleocytoplasmic transport of RNA and proteins in Xenopus oocytes
(Project Head
Pieler, Tomas
)
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A2 - Regulation des Imports von Histonen in den Zellkern
(Project Heads
Albig, Werner
;
Doenecke, Detlef
)
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A3 - Molekulare Mechanismen der Membranassoziation der Kernlamine
(Project Head
Stick, Reimer
)
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A4 - Mechanismen der Retenton von integralen Membranproteinen im ER und Golgi bei Saccharomyces cerevisiae
(Project Head
Schmitt, Hans Dieter
)
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A5 - Sortierungssignale in Membranproteinen und ihre Interaktion mit zytoplasmatischen Rezeptoren
(Project Head
Höning, Stefan
)
-
A06 - Role of AP-1 complex for intracellular protein sorting
(Project Head
Schu, Peter V.
)
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A7 - Charakterisierung und Funktionsanalyse pfalnzlicher Clathrin- und COP-coated Vesikel
(Project Heads
Holstein, Susanne E.H.
;
Robinson, David G.
)
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A08 - Assembly und Kern-Cytoplasma-Transport von U snRNPs
(Project Head
Lührmann, Reinhard
)
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A9 - Proteintransport durch die Membran des rauhen endoplasmatischen Retikulums
(Project Head
Hartmann, Enno
)
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A10 - Intracellular trafficking of chemokine receptors and associated adaptor proteins
(Project Head
Oppermann, Martin
)
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A11 - Crystal structure analysis of components involved in nucleocytoplasmic transport
(Project Head
Ficner, Ralf
)
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A14 - Transport von Determinanten der Zellpolarität in Saccharomyces cerevisiae
(Project Head
Mösch, Hans-Ulrich
)
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A15 - Proteolipid protein and cholesterol in the assembly of myelin membranes
(Project Head
Nave, Ph.D., Klaus-Armin
)
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A16 - Kristallographische Strukturanalyse regulatorischer Proteine der TGN/Endosomen Sortierung
(Project Head
Rudolph, Markus Georg
)
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A17 - Molecular mechanisms of myelin biogenesis
(Project Head
Simons, Mikael Jakob
)
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A18 - Functional analysis of the RanGAP1 SUMO-1/RanBP2 complex in interphase und mitosis
(Project Head
Melchior, Frauke
)
-
A19 - What are the mechanistic differences in the biogenesis of Cvt vesicles and autophagosomes?
(Project Head
Thumm, Michael
)
-
A20 - The nuclear transport of the histone-fold-motif proteins NFY and NC2
(Project Head
Doenecke, Detlef
)
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B1 - Struktur und Funktion von Komponenten des vesikuklären Transports zwischen endosomalen und Golgi-Kompartimenten
(Project Head
Gallwitz, Dieter
)
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B2 - Rezeptor-gekoppelte Endozytose bei Pflanzen
(Project Head
Hillmer, Stefan
)
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B3 - Mechanismen des Synaptischen Targetings
(Project Head
Südhof, Thomas Christian
)
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B4 - Kinetische Analyse von Mutanten sekretorischer Proteine
(Project Head
Neher, Erwin
)
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B5 - Charakterisierung elementarer Prozesse bei Exo- und Endoctose in Pflanzen
(Project Head
Thiel, Gerhard
)
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B06 - Characterization of early endosome fusion in vitro
(Project Head
Jahn, Reinhard
)
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B7 - Charakterisierung der SNARE-Proteine mVti1 und Vti1b durch Herstellung defizienter Mäuse
(Project Head
Fischer von Mollard, Gabriele
)
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B8 - Regulation der Biogenese synaptischer Vesikel
(Project Head
Haucke, Ph.D., Volker
)
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B09 - Regulation of SNARE mediated membrane fusion by members of the Complexin protein family
(Project Heads
Brose, Nils
;
Rosenmund, Christian
)
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B10 - Visualization of molecular events during endocytosis in synapses
(Project Head
Klingauf, Jürgen
)
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B11 - Biophysical investigations on the mechanism of SNARE assembly and disassembly
(Project Head
Fasshauer, Dirk
)
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B12 - Characterization of the Transport Mechanism of Monomeric Kinesin Unc104/KIF1A in the Nervous System of C. elegans
(Project Head
Klopfenstein, Dieter
)
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B13 - Regulation of the transport of COPI-vesicels from the Golgi to the endoplasmic reticulum (ER) in yeast
(Project Head
Schmitt, Dieter
)
-
B14 - Regulation of receptor-mediated endocytosis by Actin-binding protein 1 (Abp1) and Huntingtin-interacting protein 1R (Hip1R)
(Project Head
Wienands, Jürgen
)
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B15 - Molecular control of polarized vesicle transport by the PAR/aPKC complex in Drosophila
(Project Head
Wodarz, Andreas
)
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B16 - SNARE complex function in Ca 2+ -triggered exocytosis
(Project Head
Soerensen, Jakob Balslev
)
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N01 - Molecular mechanisms of myelin biogenesis
(Project Head
Simons, Mikael Jakob
)
-
Z01 - Zentrales Verwaltungsprojekt
(Project Head
Melchior, Frauke
)
-
Z02 - Immunelektronenmikroskopisches Service-Labor
(Project Heads
Jahn, Reinhard
;
Lührmann, Reinhard
)
