Project Details
Projekt
Metabolic regulation of macrophage function in the inflamed central nervous system (A12*)
Subject Area
Molecular and Cellular Neurology and Neuropathology
Term
since 2025
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 259373024
Monocyte-derived macrophages are important in pathogenesis of neuroinflammatory conditions like multiple sclerosis, with crucial roles in both lesion formation and resolution. We aim to study the reciprocal interactions between macrophage metabolism and function to explore metabolic remodeling as a target for supporting macrophage restorative functions in the inflamed central nervous system. We will use new molecular and functional analysis tools, gene editing and in vivo imaging to understand how macrophages change their metabolic and mitochondria properties in neuroinflammatory lesions.
DFG Programme
CRC/Transregios
Subproject of
TRR 167:
Development, function and potential of myeloid cells in the central nervous system (NeuroMac)
Applicant Institution
Technische Universität München (TUM)
Project Heads
Professor Dr. Martin Kerschensteiner; Professor Dr. Thomas Misgeld
