Immunoproteasomes in foeto-maternal immune responses and immune priming (A08)

• Subject Area: Reproductive Medicine, Urology ; Immunology
• Term: since 2025
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 534829736

The immunoproteasome is a specialized type of proteasome that is important for selecting and priming of CD8+ T cells. It is thus key for the establishment of self-tolerance, anti-viral and autoimmunity. We will here analyze the regulation of the immunoproteasome by maternal immune activation (MIA) in response to stress and infections and how this will impact anti-viral immune responses in the pregnant host, immune priming in the foetal thymus and development of tolerance in the offspring.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1713: Maternal Immune Activation: Causes and Consequences
• Applicant Institution: Universität Hamburg
• Project Head: Professorin Dr. Silke Meiners