A multiscale analysis of synaptic turnover for modeling the dynamic changes that shape synaptic function (C12*)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317475864

In our recent work, we identified brain aging as a condition that specifically slows down molecular turnover, unbalancing the mechanisms that normally ensure efficient synaptic function and plasticity. We now aim to develop a computational model of detailed synaptic turnover, and iteratively integrate the obtained experimental data, to identify the major potential bottlenecks in synaptic function (such as restriction in the availability of functional endocytic components).

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1286: Quantitative Synaptology
• Applicant Institution: Georg-August-Universität Göttingen
• Project Heads: Eugenio Fornasiero, Ph.D.; Dr. Johanna Senk