Project Details
Projekt
Uncovering the role of m¹A methylation in mitochondrial mRNA stability, translation, and function (A07*)
Subject Area
Bioinformatics and Theoretical Biology
Biochemistry
Biochemistry
Term
since 2026
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 439669440
Mitochondrial RNA modifications, including N1-methyladenosine (m1A), are thought to regulate mitochondrial (mt) translation, but their biological effects are not well understood. Here, the impact and mechanism of m1A on mt-mRNA processes such as processing, turnover, decay, translation, ribosome stalling, and double-stranded mt-mRNA formation will be addressed. A reliable method using nanopore technology will be developed to map and quantify mitochondrial modifications. Finally, the m1A mt-mRNA landscape will be examined under normal, stress, and disease conditions.
DFG Programme
CRC/Transregios
Subproject of
TRR 319:
RMaP: RNA Modification and Processing
Applicant Institution
Johannes Gutenberg-Universität Mainz
