The role of P-bodies in m6A-mediated RNA decay (B08*)

• Subject Area: General Genetics and Functional Genome Biology
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 439669440

N6-methyladenine (m6A) is the most abundant internal mRNA modification in humans, crucial for RNA stability and cellular function in health and disease. Recently, we identified a specific role for m6A sites in the coding sequence (CDS) and discovered a novel RNA decay pathway, CDS–m6A decay (CMD). This project integrates biochemical and molecular techniques to investigate m6A-mediated transcript regulation, aiming to uncover its mechanisms and implications in cancer development.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 319: RMaP: RNA Modification and Processing
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Professor Dr. Julian König, Ph.D.; Professor Dr. Frank Lyko