Checkpoints of T cell tissue egress promoting remission in inflammatory bowel disease (TP05)

• Subject Area: Dermatology ; Gastroenterology
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 550296805

Long-term remission in inflammatory bowel disease (IBD) remains rare. Our data show that the entry and exit of T cells from the inflamed intestine is crucial to regulate mucosal immune responses. Targeting the checkpoints affecting the recirculation and residence of T cells could promote remission. We therefore aim to elucidate the molecular mechanisms that control intestinal T cell egress in homeostasis and inflammation. In addition, we also study how regulatory T cells leave or remain in tissues, and optimize their migratory behavior to induce long-term remission in IBD.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1755: CASCAID - Cellular and Systems Control of Autoimmune Disease
• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Project Heads: Professorin Dr. Caroline J. Voskens; Professor Dr. Sebastian Zundler